John R Cirrito Selected Research

Serotonin (5 Hydroxytryptamine)

11/2020	Effect of escitalopram dose and treatment duration on CSF Aβ levels in healthy older adults: A controlled clinical trial.
5/2014	An antidepressant decreases CSF Aβ production in healthy individuals and in transgenic AD mice.

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John R Cirrito Research Topics

Disease

55	Alzheimer Disease (Alzheimer's Disease) 12/2023 - 08/2003
15	Amyloid Plaque 03/2016 - 02/2005
4	Dementia (Dementias) 01/2021 - 12/2010
4	Cognitive Dysfunction 01/2021 - 02/2011
4	Cerebral Amyloid Angiopathy (Congophilic Angiopathy) 02/2016 - 07/2007
3	Seizures (Absence Seizure) 07/2013 - 11/2007
2	Parkinson Disease (Parkinson's Disease) 01/2022 - 01/2021
2	Cerebral Hemorrhage 02/2015 - 01/2011
2	Sleep Deprivation 12/2014 - 11/2009
1	Respiratory Tract Diseases (Respiratory Tract Disease) 01/2023
1	Lewy Body Disease (Lewy Body Dementia) 01/2022
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2022
1	Psychotic Disorders (Schizoaffective Disorder) 01/2021
1	Astrocytoma (Pilocytic Astrocytoma) 12/2016
1	Stroke (Strokes) 02/2016
1	Ischemic Stroke 02/2015
1	Narcolepsy 12/2014
1	Amyloidosis 01/2014
1	Epilepsy (Aura) 07/2013
1	Myeloid Leukemia (Leukemia, Myelocytic) 06/2012
1	Hemorrhage 01/2011
1	Traumatic Brain Injuries (Traumatic Brain Injury) 12/2010
1	Neuroblastoma 12/2009
1	Tuberous Sclerosis (Bourneville's Disease) 11/2007

Drug/Important Bio-Agent (IBA)

37	Amyloid (Amyloid Fibrils)IBA 01/2022 - 10/2006
19	Peptides (Polypeptides)IBA 01/2021 - 10/2003
18	Amyloid beta-PeptidesIBA 01/2022 - 08/2003
8	Proteins (Proteins, Gene)FDA Link 01/2022 - 02/2005
5	ApolipoproteinsIBA 12/2016 - 03/2012
4	Apolipoproteins E (ApoE)IBA 12/2016 - 03/2012
2	Complement System Proteins (Complement)IBA 01/2022 - 01/2017
2	Biomarkers (Surrogate Marker)IBA 01/2021 - 07/2012
2	Serotonin (5 Hydroxytryptamine)IBA 11/2020 - 05/2014
2	LipidsIBA 01/2016 - 03/2015
2	OrexinsIBA 12/2014 - 11/2009
2	Apolipoprotein E4IBA 04/2013 - 07/2012
1	AerosolsIBA 01/2023
1	Aquaporins (Water Channels)IBA 01/2022
1	Aquaporin 4IBA 01/2022
1	SynucleinsIBA 01/2022
1	Cholinergic ReceptorsIBA 01/2021
1	pimavanserinIBA 01/2021
1	Cholinergic Agents (Cholinergics)IBA 01/2021
1	mouse presenilin 1IBA 11/2020
1	Escitalopram FDA Link 11/2020
1	alpha- Amino- 3- hydroxy- 5- methyl- 4- isoxazolepropionic Acid (AMPA)IBA 01/2018
1	CholesterolIBA 12/2016
1	GlycosyltransferasesIBA 03/2016
1	Sulfates (Sulfates, Inorganic)IBA 03/2016
1	ponezumabIBA 02/2016
1	Protein Isoforms (Isoforms)IBA 02/2016
1	Transcription Factors (Transcription Factor)IBA 09/2015
1	Reactive Oxygen Species (Oxygen Radicals)IBA 02/2015
1	Citalopram FDA LinkGeneric 05/2014
1	Muscarinic Receptors (Muscarinic Acetylcholine Receptor)IBA 01/2014
1	Antisense OligonucleotidesIBA 07/2013
1	tau Proteins (tau Protein)IBA 07/2013
1	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 07/2013
1	Bexarotene (LGD1069)FDA Link 05/2013
1	Levetiracetam (Keppra)FDA LinkGeneric 10/2012
1	ClathrinIBA 06/2012
1	Phosphatidylinositols (Phosphatidylinositol)IBA 06/2012
1	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 02/2011
1	GRL 8234IBA 02/2011
1	Histamine Antagonists (Antihistamines)IBA 12/2009
1	latrepirdine (dimebon)IBA 12/2009
1	Orexin Receptor AntagonistsIBA 11/2009
1	Caffeine (No Doz)FDA LinkGeneric 01/2009
1	Glutamic Acid (Glutamate)FDA Link 11/2007
1	Neprilysin (Neutral Endopeptidase)IBA 07/2007
1	Presenilin-1IBA 10/2006
1	Matrix Metalloproteinases (MMPs)IBA 08/2006
1	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 11/2005

Therapy/Procedure

3	Therapeutics 01/2014 - 08/2003
1	Catheters 12/2023